Saha Suppresses Peritoneal Fibrosis in Mice
نویسندگان
چکیده
منابع مشابه
SAHA Suppresses Peritoneal Fibrosis in Mice.
OBJECTIVE Long-term peritoneal dialysis causes peritoneal fibrosis in submesothelial areas. However, the mechanism of peritoneal fibrosis is unclear. Epigenetics is the mechanism to induce heritable changes without any changes in DNA sequences. Among epigenetic modifications, histone acetylation leads to the transcriptional activation of genes. Recent studies indicate that histone acetylation i...
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Long-term peritoneal dialysis (PD) leads to histological changes in the peritoneal membrane. Angiogenesis and inflammation caused by glucose degradation products (GDPs) play crucial roles in peritoneal fibrosis. One such GDP is methylglyoxal (MGO), which enhances the formation of advanced glycation end products (AGEs). AGEs bind to their receptor (RAGE) and activate nuclear factor-κB (NF-κB), w...
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ژورنال
عنوان ژورنال: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
سال: 2015
ISSN: 0896-8608,1718-4304
DOI: 10.3747/pdi.2013.00089